A student of Duilio Cambellotti at the Academy of Fine Arts in Rome, he was a leading exponent of Futurism and had close contacts with representatives of the European artistic avant-garde, with Dadaism with the Section d'Or, the Bauhaus, De Stijl, the Abstraction-Création group, with Pablo Picasso, Piet Mondrian, Wassily Kandinsky and Jean Cocteau, operating theoretically and practically also in the architecture sector.

In the middle of the decade (1910s), together with Balla and Fortunato Depero, he was the protagonist of the turning point of Roman futurism in the direction of a synthetic analog abstraction.

Exhibition

Enrico Prampolini. Taccuini inediti 1942-1956, Modena, Galleria Civica, Palazzina dei Giardini, 24 November 1991 - 19 January 1992, cat. pp. 201, 202, n. PC 14, illustrated;

Enrico Prampolini, Milano, Arte Centro, November 2002 - January 2003, cat. n. 63, colors illustrated (artwork dated 1949/50).